The film’s four stars, Colin Farrell, Brendan Gleeson, Barry Keoghan and Kerry Condon, have been recognized for their individual performances.
Martin McDonagh’s dark Irish comedy sees the sudden end of a relationship between two lifelong friends, Padraic Suilleabhain and Colm Doherty, played by Farrell and Gleeson.
Keoghan plays the innocent but ditzy Dominic Kearney, while Condon takes on the role of Padraic’s sister, Siobhan.
Farrell is named in the top acting category (Outstanding Performance by a Male Actor in a Leading Role) after previously triumphing at the Golden Globes and earning a coveted Oscar nomination in the equivalent categories.
Gleeson and Keoghan are up against each other for Outstanding Performance by a Male Actor in a Supporting Role, while Condon is nominated in the female category.
Keoghan and Condon recently took home awards in the equivalent Bafta categories, although Gleeson is yet to take any awards this season.
The Banshees Of Inisherin also earned a nomination for Best Cast in a Motion Picture, the SAG equivalent of Best Picture, along with The Fabelmans, Babylon, Everything Everywhere All At Once and Women Talking.
Other contenders competing with Farrell in the Outstanding Actor in a Leading Role category include Bill Nighy, Adam Sandler, Brendan Fraser and Austin Butler.
Butler, who is also an Oscar nominee for his portrayal of Elvis Presley in the Baz Luhrmann biopic, beat out the Irish actor last week to claim the Bafta award for best actor.
In the SAG category for Outstanding Performance by an Actress in a Leading Role, Oscar nominees Cate Blanchett, Michelle Yeoh and Ana de Armas received nominations, as did Viola Davis and Danielle Deadwyler.
On the small screen, British names have received fewer SAG nominations, although the royal drama The Crown is recognized in the category for Outstanding Performance by an Ensemble in a TV Drama Series.
It is up against popular American series like The White Lotus, Severance, Ozark and HBO’s Better Call Saul for the award.
Taron Egerton and Emily Blunt are nominated for Best Performance by a Male and Female Actor in a TV Movie or Miniseries, respectively.
The 29th annual ceremony, which begins at 1am UK time, will take place at the Fairmont Century Plaza in Los Angeles.